Study of the level of (TNF-ɑ), oxidative stress and some biochemical parameters in patients With Hypothyroidism in the city of Samarra

• adwa fezaa jassim,*  
• Qaisar mashan abd

Abstract

Hypothyroidism is the insufficient production of thyroid hormone by the thyroid gland to satisfy the body's metabolic needs. Untreated hypothyroidism may lead to hypertension, lipid problems, infertility, cognitive impairment, and neuromuscular dysfunction. Hypothyroidism may arise due to insufficient thyroid stimulation from the hypothalamus or pituitary gland. Primary gland failure may occur due to congenital abnormalities, autoimmune damage (such as Hashimoto's disease), or iodine shortage.The research included obtaining 76 blood serum samples, consisting of 50 samples from individuals with hypothyroidism and 26 samples from healthy individuals serving as the control group. The samples were gathered from outpatient clinics in the city of Samarra between September 2023 and January 2024. The participants' ages spanned from 30 to 55 years in order to assess the levels of tumor necrosis factor (TNF-ɑ), hormones (T3), (T4), and (TSH), as well as measure superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA). Additionally, the insulin levels were measured in both the hypothyroid patient group and the control group. The findings demonstrated a noteworthy elevation in the probability level (P ≤0.05) of TNF-ɑ, TSH, MDA, and Insulin, as well as a substantial reduction at the probability level (P ≤0.05) of T3, T4, SOD, and GSH in the patient group as compared to the control group.

Keywords

Hypothyroidism , (TNF- ɑ) ,(TSH) , ( SOD) ,Insulin.