RESEARCH ON A PROTECTIVE EFFECT OF VITAMIN D IN THE CONTEXT OF COVID 19 IN ADULTS ON WEST AFRICAN HEMODIALYSIS

• SAGOU ERIC DIDIER YAYO,*  
• YAO EPSE YAPO CARINE MIREILLE,  
• KACOU MOREL KOUAKOU,  
• MELISSA NANIHIO,  
• ASSEYPO MARIE LAURE HAUOUHOT

Abstract

Context Chronic kidney disease is a worldwide disease with an estimated prevalence of 10% in 2020. In Côte d'Ivoire, the prevalence of this disease is not well known, but hospital studies show prevalences of 7 to 46%. In 2020, hemodialysis patients are particularly at risk of contracting COVID-19. Studies have shown that vitamin D supplementation can not only reduce the risk of getting acute respiratory infections, but has also been associated with a lower susceptibility to severe COVID-19. To this end, a study was undertaken to assess the impact of the pandemic on hemodialysis patients in the public sector of Abidjan, according to their vitamin D status. Methods In a cross-sectional study conducted from November 2021 to August 2022, we included 280 patients with end-stage CKD treated with hemodialysis at the CNPTIR in Abidjan. The collection of epidemiological and clinical data was done on the basis of a questionnaire on the one hand and the medical records of the patients on the other. Vitamin D concentration and COVID-19 serology were determined by the ELFA method with immunochemical detection. Results The mean age of the patients was 45.90 ± 12.76 and 66.85% of them were men. 42.70% of patients had been dialysis for more than 5 years. 3/4 of the study population had a positive serology for COVID-19. The mean vitamin D concentration in patients was 23.04 ng/ml of which 38.20% were vitamin D deficient. 94.57% of patients did not experience severe signs of COVID-19. There was no significant difference between mean vitamin D concentrations in serology-positive versus serology-negative patients, and mean vitamin D values in patients with severe and non-severe symptomatology. Conclusion : Our study did not show a protective effect of vitamin D against covid-19 in Ivorian hemodialysis patients.

Keywords

COVID-19, Vitamin D, hemodialysis, west african