Introduction: Vitamin D receptors present in the thyroid tissue have a direct regulatory role in thyroid hormone synthesis and function. This study is to compare the levels of Vitamin D3 in hypothyroid and euthyroid subjects.
Materials and Methods: After obtaining ethical clearance, 65 subjects with a definite diagnosis of hypothyroidism from medicine or surgery outpatient departments and 65 euthyroid subjects underwent Vitamin D3 estimation at a tertiary care hospital.“Endocrine Society Clinical Practice Guidelines” defines vitamin D deficiency (VDD) as levels<20>
Results: Group-1 consisted of 65 hypothyroid subjects (20 males and 45females) with thyroid stimulating hormone (TSH) values over 10 µIU/ml with mean age of 42.66 ± 9.40 years. Group-2 consisted of 65 euthyroid subjects (23males and 42 females) who were matched for age and sex with mean age of 41.41 ± 9.02 years. T3, T4 and Vitamin D3 levels were significantly lower while TSH levels were significantly higher in the case group. On analyzing the correlation between the thyroid profile and vitamin D3 levels, it was found that there was significant negative correlation between TSH and Vitamin D3 levels. (Pearson’s correlation coefficient -0.491, with p value <0>
Conclusion: The statistically significant low levels of Vitamin D3 in the case group emphasizes the need to routinely do Vitamin D3 estimation in hypothyroid subjects as well as to check thyroid function tests in all cases with low Vitamin D3 levels
Keywords: Vitamin D3, Hypothyroidism, Thyroid Stimulating Hormone (TSH)
