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Association of gamma glutamyl transferase activity with fasting glucose among first degree relatives of type 2 diabetes patients

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Original Article

Author Details : C M Maithr*, P Manoj, S K Mahadev, Tejaswani

Volume : 6, Issue : 4, Year : 2019

Article Page : 458-463

https://doi.org/10.18231/j.ijcbr.2019.096

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Abstract

Introduction and Objectives: Serum gamma glutamyl transferase (GGT) activity has been considered
to play an important role in the pathogenesis of diabetes. Therefore, the objectives of our study was
to determine the association of GGT with fasting glucose among first degree relatives (FDR’s) of type
2 diabetes patients and to correlate GGT with body mass index (BMI), Blood pressure (BP), waist
circumference (WC) and lipid profile parameters among FDR’s of type 2 diabetes patients.
Materials and Methods: In this study, 150 non-diabetic FDR’s of type 2 diabetic patients were enrolled.
The analysis included anthropometric measur ements, BP and estimation of fasting glucose value, lipid
profile and GGT. Based on fasting glucose value and according to American Diabetic Association criteria,
the study subjects were classified into euglycemic, prediabetic and diabetic groups.
Results: Among 150 FDR’s of type 2 diabetic patients, 36%, 31.3% and 32.7%subjects were euglycemic,
pre diabetic and diabetic respectively. There was a positive correlation between GGT and systolic BP
(r=0.205, p=< 0 r=0.198, r=0.198,> 0.05). There was a significant negative correlation between GGT and HDL(r=-0186, p<0> a significant association between fasting glucose and area under the curve (AUC) of GGT (AUC= 0.722,
P<0> value for type 2 diabetes was 29U/L.
Conclusion: Elevated levels of GGT, although in normal ranges, especially at higher quartiles play an
important role as a predictor of diabetes among FDR’s of type 2 diabetic patients.

Keywords: Gamma glutamyl transferase, First degree relatives, Euglycemia, Predia betes, Diabetes.

How to cite : Maithr C M, Manoj P, Mahadev S K, Tejaswani, Association of gamma glutamyl transferase activity with fasting glucose among first degree relatives of type 2 diabetes patients. Int J Clin Biochem Res 2019;6(4):458-463

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