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Study of microalbuminuria as a nephropathic marker in type 2 diabetes mellitus and its correlation with the glycated hemoglobin

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Original Article

Author Details : Patil A R, Paunipagar P V*

Volume : 6, Issue : 4, Year : 2019

Article Page : 479-484

https://doi.org/10.18231/j.ijcbr.2019.100

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Abstract

Diabetic nephropathy is the main cause of morbidity and mortality in patients with diabetes mellitus. The
results of many clinical studies shows variation in the correlation of HbA1c and microalbuminuria in type
2 diabetes mellitus. In the present study we tried to correlate the HbA1c levels and microalbuminuria with
respect to duration in type 2 diabetes mellitus cases and also studied microalbuminuria as a marker of
nephropathy in type 2 diabetes mellitus.
Materials and Methods: The study was conducted in the Department of Biochemistry at Raichur Institute
of Medical Sciences. 100 subjects were recruited based on the inclusion and exclusion criteria, 50 were
healthy controls and 50 were type 2 DM patients. FBS, PPBS, blood urea, serum creatinine, HbA1c, serum
sodium, serum potassium and urinary micro albumin were analyzed. Statistical analysis was done by using
student ‘t’ test and Chi square test.
Results: A statistically significant difference was observed in values of FBS, PPBS, blood urea, serum
creatinine, HbA1c, serum sodium, serum potassium and urinary microalbumin levels in cases compared
to controls. In our study the mean HbA1c values were 5.1321.11% in controls and 7.5121.19%
in cases & mean HbA1c value in patients without microalbuminuria is 7.130.84 and in patients with
microalbuminuria is 8.121.44 which is statistically significant (p=0.005).
Conclusion: The present study concluded that estimating glycosylated hemoglobin as an indicator
of glycemic control and microalbuminuria in random urine sample for renal involvement in diabetic
subjects provide a convenient method for early diagnosis and intervention. Thus the study suggests
microalbuminuria as a nephropathic marker in type 2 diabetes mellitus. The possibility, delay or reverse
the progression of diabetic nephropathy can be achieved only by perfect long term metabolic control.

Keywords: Diabetic Nephropathy, HbA1c, Microalbuminuria, Type 2 Diabetes Mellitus.

How to cite : Patil A R, Paunipagar P V, Study of microalbuminuria as a nephropathic marker in type 2 diabetes mellitus and its correlation with the glycated hemoglobin. Int J Clin Biochem Res 2019;6(4):479-484

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