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Can GGT and LDH be indicators of endothelial vascular damage in Preeclampsia?

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Original Article

Author Details : Vanishree B*, C D Dayanand, Sheela S R

Volume : 6, Issue : 4, Year : 2019

Article Page : 571-574

https://doi.org/10.18231/j.ijcbr.2019.118

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Abstract

Introduction: Preeclampsia is a metabolic syndrome and a major cause of maternal, fetal and neonatal
mortality and morbidity. Evidences prove that endothelial cell and altered endothelial cell function
play an important role in the pathogenesis of preeclampsia. The objective was to determine serum
lactate dehydrogenase (LDH) and serum gamma glutamyl transferase (GGT) as biochemical markers in
preeclamptic pregnant women and its comparison with normal pregnant women in third trimester.
Materials and Methods: Retrospective case control study was carried out in R.L. Jalappa Hospital and
Research Center, Kolar. Normal pregnant women (n=50), women with preeclampsia (n=50) were included
in the study. Both the groups were in their third trimester and of same age.
Results: Mean of Systolic and diastolic blood pressures (150/101 mm/Hg), GGT (20U/L) and LDH
(756U/L) were significantly elevated in women with Preeclampsia than in normal pregnancies. However,
Hemoglobin, has not showed significance change between the two groups.
Conclusion: In preeclampsia, vascular endothelial damage may lead to multi organ dysfunctions like liver,
kidney, lungs, nervous & coagulation system that leads to excessive LDH leakage and elevated levels in
serum due to cellular dysfunction. GGT a microsomal enzyme increases in hepatic injury, however in the
current study the increased GGT levels shows that not only by hepatic origin but its levels are also increased
in tissue damage during preeclampsia as a major cause of endothelial vascular damage. Elevated levels of
serum LDH and serum GGT indicates the tissue damage related to endothelial vascular damage and is the
main cause of preeclampsia.

Keywords: Gamma glutamyl transferase, Hemoglobin, Lactate dehydrogenase, Normotensive pregnant women, Preeclampsia.

How to cite : Vanishree B, Dayanand C D, Sheela S R, Can GGT and LDH be indicators of endothelial vascular damage in Preeclampsia?. Int J Clin Biochem Res 2019;6(4):571-574

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