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Post-prandial dylipidemia and elevated serum ferritin levels in type 2 diabetes mellitus patients: A risk marker for accelerated atherosclerotic cardiovascular events

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Original Article

Author Details : Manjula Halevoor Siddarajaiah*, Laxmi Hanumathayya Shetty, Sathyavathi Shivalinge Gowda, Nandini Mudalahalli Puttamasthi Gowda, Chollenahally Nanjappa Manjunath

Volume : 6, Issue : 4, Year : 2019

Article Page : 590-595

https://doi.org/10.18231/j.ijcbr.2019.122

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Abstract

Aims and Objectives of the Study: The type 2 diabetes mellitus (T2DM) prevalence is increasing
worldwide at alarming rates. The prevalence of T2DM is expected to be more than 350 million people
worldwide in next 20 yrs. The risk of coronary and peripheral artery disease increases by 2 to 4 fold, while
the risk of stroke is increased by 10 fold in type 2 diabetes mellitus patients.
In type 2 diabetes mellitus, dyslipidemia plays an important role in the pathogenesis of accelerated
atherosclerosis. Hyperlipidemia in postprandial state is thought to play an important role in atherosclerosis,
and concentrations of triglycerides(TG) in post prandial state are superior to those of fasting TG for
predicting cardiovascular disease.
Increase in serum ferritin levels are associated with insulin resistance(IR), systemic inflammation,
metabolic syndrome(MetS), type 2 diabetes mellitus and cardiovascular disease. Elevated body iron stores
may contribute to insulin resistance through chronic inflammation and oxidative stress.
The present study is under taken to assess the implication of post prandial dyslipidemia in comparison to
fasting dyslipidemia in the pathogenesis of cardiovascular disease and to show the importance of increased
serum ferritin levels in type 2 diabetes patients which acts as a potential risk marker for coronary artery
disease.
Materials and Methods: Fifty type 2 diabetes mellitus patients and fifty normal adults between age
group 30-75yrs attending Medicine OPD, Rajarajeswari Medical College and Hospital, Bangalore were
scree ned for lipid profile using enzymatic method by ERBA 360 autoanalyzer and serum ferritin levels by
chemiluminiscence method. The statistical analysis was done by students unpaired t-test.
Results: Serum lipid profile including TGs, LDL-C, VLDL-C were significantly increased in the postprandial
state as compared to the fasting state in cases with p<0> elevated in cases, compared to controls with p<0> state compared to fasting state in cases with p<0> in cases when compared with controls with p 0.006. Serum ferritin was significantly elevated in cases,
compared controls with p<0> Conclusion: In the present study there was significant postprandial dyslipidemia in type 2 diabetes
mellitus patients as compared to fasting dyslipidemia. We also noticed the significant increase in serum
ferritin levels in these patients when compared to controls, which could be one of the causes for insulin
resistance. Hence post prandial lipid profile and estimation of serum ferritin should be included as a routine
cardiovascular risk assessment marker for evaluation in type 2 diabetes mellitus patients for early detection
and prompt therapy.

Keywords: TC (Total cholesterol), TGs (Triglycerides), LDLC (Low density lipoproteins), HDL (High density lipoprotein), VLDLC (Very low density
lipoprotein).

How to cite : Siddarajaiah M H, Shetty L H, Gowda S S, Gowda N M P, Manjunath C N, Post-prandial dylipidemia and elevated serum ferritin levels in type 2 diabetes mellitus patients: A risk marker for accelerated atherosclerotic cardiovascular events. Int J Clin Biochem Res 2019;6(4):590-595

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