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High-sensitivity C-reactive protein, Malondialdehyde and their association with Glycated hemoglobin (HbA1c)in type 2 diabetes patients

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Original Article

Author Details : T Santhi*, K Balu Mahendran

Volume : 7, Issue : 1, Year : 2020

Article Page : 57-61

https://doi.org/10.18231/j.ijcbr.2020.012

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Abstract

Introduction: Type 2 diabetes mellitus is a major public health problem worldwide and accompanied by
enduring vascular complications, which leads to morbidity and mortality. Inflammation play major role in
the pathogenesis of type 2 diabetes mellitus. High sensitivity C-reactive protein is an acute phase protein
synthesized by the liver and has been revealed as sensitive, systemic inflammatory marker. Oxidative
stress, low grade systemic inflammation contributes to insulin resistance and is linked to the characteristics
of metabolic syndrome and type 2 diabetes mellitus.
Objectives: The present study was to evaluate hs - CRP, malondialdehyde (MDA) levels in type 2 diabetic
patients compare with healthy controls and correlate these levels with glycated hemoglobin (HbA1C) and
insulin resistance
Materials and Methods: Fifty type 2 diabetic patients with age group of 35 to 45 years were selected for
this study and 50 age matched healthy subjects were selected as controls. Ser um hs- CRP and insulin was
assessed by ELISA, malondialdehyde (MDA) was assessed by Thiobarbituric Acid Reactive Substances
(TBARS) method and other routine investigations were carried out by standardized protocols with ERBA
EM-360 fully automated analyzer.
Results: The mean serum hs - CRP and MDA levels were significantly increa sed in type 2 diabetic patients
com pared with healthy controls. Hs-CRP and MDA levels w ere shown significant positive correlation
with glyc osylated hemoglobin (HbA1C), insulin resistance, triglycerides and negative correlation with
HDL cholesterol.
Conclusion: Elevated hs - CRP, MDA levels are potentially important diagnostic markers for the
assessment of endothelial dysfunction in type 2 diabetic patients. Tight blood glucose control, regular
monitoring of hs-CRP, MDA levels within normal range might be useful for reduction of vascular
complications in type 2 diabetic patients.

Keywords: Type 2 diabetes mellitus (T2DM), High sensitivity C- reactive protein (hs-CRP), Malondialdehyde (MDA), Glycosylated hemoglobin (HbA1C), Insulin resistance (IR).

How to cite : Santhi T, Mahendran K B, High-sensitivity C-reactive protein, Malondialdehyde and their association with Glycated hemoglobin (HbA1c)in type 2 diabetes patients. Int J Clin Biochem Res 2020;7(1):57-61

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