International Journal of Clinical Biochemistry and Research
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2394-6369
Online ISSN: 2394-6377
CODEN : IJCBK6
International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...Original Article
Author Details :
Volume : 7, Issue : 2, Year : 2020
Article Page : 158-163
https://doi.org/10.18231/j.ijcbr.2020.034
Abstract
Background: Beta-Thalassemia is a genetic disorder which is associated with a lot of complications. Frequent blood transfusions result in increased iron deposition in various tissues leading to dysfunction of many vital organs. Endocrine disorders constitute a major part of such complications increasing the morbidity of thalassemia manifold in the affected patients. Early diagnosis of hypoparathyroidism (HPT) could prevent other severe disorders such as Tetany, seizures, osteopenia, and osteoporosis. Growth retardation can occur as complication of thalassemia as early as the 1st or 2nd year of life but these abnormalities more prominent after the 6 – 8 years of life.
Aim & Objectives: The aim of this study was carried out to determine; 1. The prevalence of (HPT) and Growth retardation in patients with beta and to correlate them with serum , calcium, phosphorus and alkaline levels; 2. The relationships of growth failure with certain variable including age, serum , mean hemoglobin level and gender of the patients.
Materials and Methods: This is a descriptive research study which was conducted on 200 subjects (100 cases and 100 controls) in the age group of 10-25 years who had visited the OPD/IPD of Subharti Medical College & affiliated Hospitals, . The cases included were with confirmed diagnosis of beta major, with regular blood transfusions and serum levels >2000 /ml irrespective of therapy.
Results: Out of 100 patients, was diagnosed in 18% patients, Growth retardation/ Short stature 93% and Weight loss was found in 93% patients. The mean age at diagnosis was 12.6 years (range 11-16 years), mean serum calcium was 7.53 mg/ (range7.58-9.04 mg/), mean serum was 5831.0 /ml (range 2000-8,064 /) and mean serum phosphate was 5.63 mg/ (range 4.50-7.73 mg/). Serum parathyroid hormone (PTH) levels were low in most of the patients. Short stature was observed in most of the patients, while it was found normal in control subjects.
Significant (HPT) observed along with growth retardation in beta patients (p < 0>
Keywords: Hypoparathyroidsm, Growth retardation, b - Thalassemia, Parathormone.
How to cite : Manne N , Yadav S K, Gupta B K, Singhal S , Dubey A, Prevalence of hypoparathyroidism, growth retardation in patients of Beta-thalassemia major. Int J Clin Biochem Res 2020;7(2):158-163
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