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Evaluation and comparison of antioxidant status in ischemic and haemorrhagic cases of stroke

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Original Article

Author Details : Rahul Kumar Shukla, B K Agrawal*, Amit Kumar

Volume : 7, Issue : 2, Year : 2020

Article Page : 176-180

https://doi.org/10.18231/j.ijcbr.2020.038

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Abstract

Introduction: The World health organization (WHO) has defined stroke as “rapidly developing clinical
signs of focal (or global) cerebral function, with symptoms lasting 24 hours or longer or leading to death,
with no apparent cause other than vascular region.”
Material and Methods: This case-control study was conducted on 145 individuals (58 ischemic strokes
and 29 haemorrhagic strokes as the case groups; 58 healthy individuals as the control group).
Diagnosis: The diagnosis of stroke was based on history, clinical examination and brain CT scan was used
to confirm and classify as ischemic or haemorrhagic stroke cases.
Results: A total of 87 cases of stroke (58 ischemic stroke, 29 haemorrhagic strokes, and 58 healthy
individuals as the control group) were identified during the study follow-up. Glutathione peroxides (GPX)
levels are reduced significantly in Ischemic Stroke Patients (ISPs) and haemorrhagic stroke Patients (HSPs)
equated with control subjects (p<0> Conclusion: Finally, positive direct relationship was seen in MDA along with infarct size. So, it could
consider as a bio marker for diagnosis of stroke. This could be valued for improving the dose frequency for
improvement of patient health. From these studies, we can conclude that antioxidant defence is reduced in
ischemic stroke patients as a significance of inclined oxidative stress.

Keywords: Oxidative stress, Antioxidant, Ischemic, Haemorrhagic

How to cite : Shukla R K, Agrawal B K , Kumar A , Evaluation and comparison of antioxidant status in ischemic and haemorrhagic cases of stroke. Int J Clin Biochem Res 2020;7(2):176-180

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