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Comparative study of glomerular filtration rate estimatation by formulae using two different methods for creatinine estimation in chronic kidney disease

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Original Article

Author Details : B Bhanuja Rani, Lavanya Lagisetty*, A Sujatha Rani, T Kinnera

Volume : 7, Issue : 2, Year : 2020

Article Page : 221-225

https://doi.org/10.18231/j.ijcbr.2020.048

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Abstract

Ckd is rapidly raising epidemic with increasing prevalence in India due to raised diabtes and hypertension
cases. This is a Prospective crosssectional study & proven cases of Ckd (n = 100) admitted in the
hospital between March 2014- August 2015. at Gandhi Hospital were included in the study. Serum
creatinine was measured by Jaffe’s and creatininase-creatininase methods and gfr was calculated using
conventional formula and Cockcroft-gault formula. 100 patients were selected with male predominance
(1.5:1) and average mean age group of 5th to 6th decade are the Ckd cases.This study established that the
clearance measured by 24-hour urine collection has inherent errors, and determined that the CGF formula
produces better results closest to the clinical symptoms and condition of chronic kidney disease, than the
creatinine clearance obtained with conventional method (i.e., 24-hour urine collection) in patients, stating
that creatinine clearance obtained by using enzymatic creatinine method with COCKCROFT –GAULT
formula correlates better.

Keywords: Chronic kidney disease, Jaffe’s fixed kinetic method, Enzymatic method, Measured creatinine clearance, Cockcroft-gault method.

How to cite : Rani B B, Lagisetty L , Rani A S, Kinnera T , Comparative study of glomerular filtration rate estimatation by formulae using two different methods for creatinine estimation in chronic kidney disease. Int J Clin Biochem Res 2020;7(2):221-225

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