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Comparative evaluation of enzymatic and non-enzymatic antioxidants in alzheimer dementia

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Original Article

Author Details : Balasaheb H Jadhav, Madhav G Kalekar*, Syed Abdul Jaweed, Poornima Shelke

Volume : 7, Issue : 2, Year : 2020

Article Page : 232-237

https://doi.org/10.18231/j.ijcbr.2020.050

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Abstract

The senile dementia is a neurodegenerative disease characterized by loss of memory, attention and
cognitive functions. The oxidants- antioxidant plays important role by several mechanism by reducing toxic
Amyloid-b in neurons The Alzheimer’s disease is due to Amyloid-b deposition in the brain and production
of neurofibrillary tangles. Amyloid-b induces reactive oxygen species in brain of Alzheimer dementia
patients. In the present study we evaluated the levels of Superoxide dismutase, Glutathione peroxidase,
Catalase, Vitamin C and Vitamin E and Vitamin B6 in Alzheimer dementia patients. It has been observed
lower levels of Enzymatic, Non-Enzymatic Antioxidants and increased serum levels of malondialdehyde
significantly in Alzheimer’s dementia patients as compared to healthy controls (p < 0> oxidative stress markers may play important role in neurodegenerative diseases like Senile dementia. Serum
levels of Superoxide dismutase, Glutathione peroxidase, Catalase, Vitamin C and Vitamin E and Vitamin
B6 and Malondialdehyde (indicator of Lipid peroxidation) were measured using standard methods in 50
healthy controls and 50 Alzheimer’s dementia patients.

Keywords: Superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px), MDA (Malondialdehyde), Ascorbic acid (Vit C), Alpha-Tocopherol (Vit E), Amyloid-b (Ab), Reactive oxygen species (ROS).

How to cite : Jadhav B H, Kalekar M G, Jaweed S A, Shelke P , Comparative evaluation of enzymatic and non-enzymatic antioxidants in alzheimer dementia. Int J Clin Biochem Res 2020;7(2):232-237

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