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Serum lipids in sub clinical hypothyroidism: A retrospective study

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Original Article

Author Details : Audi Bhagyalakshmi, Amrut Arvindrao Dambal*, D Sridevi, Prabhavati Modi, Lakshmi Chaitanya

Volume : 7, Issue : 2, Year : 2020

Article Page : 260-263

https://doi.org/10.18231/j.ijcbr.2020.056

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Abstract

Background: Thyroid hormones are a potent regulator of metabolism, playing a crucial role in regulating
energy expenditure and in key physiological mechanisms. Their prominent and well-known role is an
increase in basal energy expenditure obtained by acting on carbohydrate, protein and lipid-metabolism.
Hypothyroidism is relatively common and is associated with an unfavorable effect on lipid metabolism. Few
studies reveal subclinical hypothyroidism to be a risk factor for increased incidence of lipid abnormalities
and resulting in cardiovascular abnormalities.
Aim: Hence study was taken up to find the association of serum lipids with subclinical hypothyroidism.
Methodology: This was a retrospective study conducted in the department of Biochemistry, Malla Reddy
hospital. Biochemically identified 102 subjects of Subclinical hypothyroidism subjects between 15-50 years
and evaluated for lipid profile were included in the study. In our study, the mean serum total cholesterol,
triglycerides, HDL cholesterol and LDL cholesterol expressed in mg/dl were 189.9824.16, 166.48+17.4,
37.62+2.89 and 121.34+27.31mg/dl respectively. 41 subjects out of 102 had higher total cholesterol,
triglycerides and LDL cholesterol with lesser HDL cholesterol from the acceptable limits.
Conclusion: We conclude that impaired lipid parameters are associated with subclinical hypothyroidism.
Hence a regular screening for lipid profile should be considered in subclinical hypothyroidism for early
diagnosis, prevention and management of cardiovascular complications.

Keywords: TSH, HDL cholesterol, LDL cholesterol, Sub clinical hypothyroidism.

How to cite : Bhagyalakshmi A , Dambal A A, Sridevi D , Modi P , Chaitanya L , Serum lipids in sub clinical hypothyroidism: A retrospective study. Int J Clin Biochem Res 2020;7(2):260-263

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