---

Relationship between adiponectin & uric acid with inflammation in pathogenesis of metabolic syndrome

---

Original Article

Author Details : Prema Adhikari, Suryakant Nagtilak*, Pawan Parashar

Volume : 7, Issue : 3, Year : 2020

Article Page : 343-348

https://doi.org/10.18231/j.ijcbr.2020.074

Suggest article by email

Get Permission

---

Abstract

Background: The risk factors of Metabolic syndrome (Mets), primarily favors the development of
cardiometabolic alteration, type 2 diabetes, hypertension, and dyslipidemia leading to increase in morbidity.
Life style and eating habits often increases the levels of Uric acid (UA) in circulation. Elevated UA &
stress, exacerbates the pain and inflammation. The inflammatory response includes systemic increase in
circulating inflammatory cytokines and acute phase protein, high sensitive C-reactive protein (hs-CRP).
Adiponectin (ADI) a cytokines primarily secreted by adipocytes exerts antidiabetic, anti-inflammatory &
cardioprotective effects. Thus the purpose of the study is to establish a link between Adiponectin, Uric acid
and hs-CRP which may further be used in diagnosis and thus can positively reverse many of the adverse
effects of MetS.
Material and Methods: Present study, an observational case-control study conducted on referred MetS
patients attending OPD at Chhatrapati Shivaji Subharti Hospital, Meerut. Data collected on previously
validated questionnaire from 235 subjects (156 with MetS and 79 non-MetS) assessed for anthropometric
measurements, diabetic profile, ADI, UA & hs-CRP were evaluated by standard established techniques.
Results: The results obtained from Mets patients were compared with non-MetS subjects, where ADI was
significantly lower (P<0> In Spearman’s rank correlation coefficient for the relationship between ADI and metabolic variables -
ADI was positively correlated with age, diastolic blood pressure, total cholesterol, HDL-C& LDL-C
while negatively correlated with BMI, systolic blood pressure, fasting glucose, Triglyceride& VLDL-C.
Serum hs-CRP levels were elevated with the increasing number of MetS components, being higher among
those with > 2 components of MetS while adiponectin decreasing with the number of MetS components.
Decreased levels were reported for ADI, whereas hs-CRP & UA levels were escalating.
Conclusion: Higher levels of hs-CRP & Uric Acid with lower level of ADI associated with significantly
higher risk of MetS.

Keywords: Obesity, Adiponectin, Uric acid, hs-CRP, Metabolic syndrome.

How to cite : Adhikari P , Nagtilak S , Parashar P , Relationship between adiponectin & uric acid with inflammation in pathogenesis of metabolic syndrome. Int J Clin Biochem Res 2020;7(3):343-348

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.