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Evaluation of fasting plasma glucose, lipid profile and thyroid stimulating hormone as predictors of gestational diabetes mellitus

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Original Article

Author Details : Vatturi Saumya*

Volume : 7, Issue : 3, Year : 2020

Article Page : 357-360

https://doi.org/10.18231/j.ijcbr.2020.077

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Abstract

Objective: To evaluate the usefulness of fasting plasma glucose, lipid profile, and thyroid-stimulating
hormone (TSH) estimated at first trimester in predicting gestational diabetes mellitus.
Materials and Methods: A prospective study was done. Samples were collected after 12 hours of fasting
from 250 women within the gestational age of 12 weeks and were analyzed for plasma glucose, lipid
profile, and TSH in the fully automated analyzers EM 200 and Cobas e411 by enzymatic and electro
chemiluminescence immunoassay respectively. Oral glucose tolerance test (OGTT) with 75 gm was
performed in these subjects at 24 -28 weeks of gestational age. Data was analyzed using SPSS 19.0. To
analyze statistically significant differences in means of continuous variables between 2 groups, a student
t-test was used. Multiple logistic regression analyses were performed to find the presence of association of
these independent variables with GDM.
Results: Out of 250 pregnant women, 51 (25%) developed GDM, 149(75%) had normal glucose tolerance.
GDM was found to have an association with fasting plasma glucose with (OR 2.846,1.506- 5.362, P <
0.001), total cholesterol (OR 1.136, 1.072-1.120, P = 0.04), triglycerides (OR 1.464,1.361-1.565,P = 0.003),
low density cholesterol (LDL-C) -(OR 1.253, 1.173-1.338,P=0.009), and no association with TSH.
Conclusion: Estimation of fasting plasma glucose, lipid profile in the first trimester can be predictors of
GDM, whereas TSH can not be a predictor of GDM.

Keywords: First trimester, Fasting plasma glucose, Gestational diabetes mellitus, Lipid profile, TSH.

How to cite : Saumya V , Evaluation of fasting plasma glucose, lipid profile and thyroid stimulating hormone as predictors of gestational diabetes mellitus. Int J Clin Biochem Res 2020;7(3):357-360

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