International Journal of Clinical Biochemistry and Research
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2394-6369
Online ISSN: 2394-6377
CODEN : IJCBK6
International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...Original Article
Author Details :
Volume : 7, Issue : 4, Year : 2020
Article Page : 473-477
https://doi.org/10.18231/j.ijcbr.2020.100
Abstract
Introduction: Present study was conducted to investigate the oxidative, stress by measuring the lipid peroxidation marker Malondialdehyde (MDA) in maxillary cancer and vocal cord cancer. And, to study the role of non-enzymatic antioxidants like ascorbic acid (vitamin C) and tocopherols (vitamin E) in maxillary cancer and vocal cord cancer.
Materials and Methods: Total 100 patients were selected.
Inclusion Criteria: Study included Maxillary and Vocal cord patient.
Exclusion Criteria: The exclusion criteria were male factor chronic disease like chronic heart disease (CHD), hypertension, ischemic heart disease, diabetes mellitus (DM), chronic obstructive pulmonary disease (COPD), other major systemic illness in different age group. MDA estimation done by Thiobarbituric acid reactive substance (TBARS) (Buege and Aust,1978) method and vitamin C determined by the method of Natelson, (1971) and Vitamin E by Baker and Frank method.
Results: Majority of patient were between age group 41 to 60 years. Here, Mean MDA, Vitamin-C and E Level in case and control was 7.09±2.15 and 2.3±1.06; 0.225±0.067 and 0.998 ± 0.19 and 0.456±0.155 and 1.02±0.167 respectively.
Conclusion: Maxilla and vocal cord cancer is a major cause of morbidity and mortality in both developingand developed countries. We found an associations of vitamin C (Ascorbic acid), vitamin E (Tocopherol) and MDA with oral cancer.
Keywords: MDA, Oxidative stress, Vitamin-C, Vitamin-E.
How to cite : Kanwar A , Mor P , Sonagara V , Status of lipid peroxidation and antioxidation in maxillary and vocal cord carcinoma. Int J Clin Biochem Res 2020;7(4):473-477
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