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Insulin resistance and dysglycaemia in polycystic ovary syndrome patients

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Original Article

Author Details : Kwadjo Anicet Luc Dere*, Agnon Prisca Djoupo, Messou Michèle Menin, Djenebou Coulibaly, Gnomblesson Georges Tiahou

Volume : 7, Issue : 4, Year : 2020

Article Page : 478-483

https://doi.org/10.18231/j.ijcbr.2020.101

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Abstract

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathy occurring during women reproductive age marked by a large range of metabolic disorders and abnormalities.
Materials and Methods: This study was conducted in Bouaké Teaching Hospital. The diagnosis of PCOS was confirmed according to the revised Rotterdam criteria. Firstly, we established the diagnosis of PCOS through the measurement of different hormonal parameters and on the basis of ultrasonography and disease’s history. Secondly, we met patients to realize different tests aimed to explore glucose metabolism.
The oral glucose tolerance test was performed each 30 minutes after administration of 75 g of oral glucose.
Results: We noted that 17% of PCOS patients had a HOMA Insulin Resistant in contrary to 83% of patients with a HOMA insulin sensitive state and obesity was significantly more prevalent in the IR group. PCOS patients HOMA IR group had a mean BMI significantly higher than those of IS group. Out of 12 insulinresistant PCOS patients, 01 had normal BMI and 11 were overweight or obese (91.70%) contrary to those in IS group within 47.45% had normal BMI and 52.54% were overweight or obese. In the subgroup of IR with high BMI, we noticed the higher values of glycaemia. The rate of dysglycaemia was more prevalent
in this subgroup following by IS with high BMI group.
Conclusion: The rate of PCOS patients with HOMA-IR was important and was correlated to anthropometric disorders and high level of LH and testosterone. To successfully handling this important endocrinopathy, it’s strongly advised to early diagnosed PCOS.

Keywords: Insulin resistance, Dysglycaemia, Polycystic ovary, Syndrome.

How to cite : Dere K A L , Djoupo A P, Menin M M , Coulibaly D , Tiahou G G , Insulin resistance and dysglycaemia in polycystic ovary syndrome patients. Int J Clin Biochem Res 2020;7(4):478-483

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