International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377

CODEN : IJCBK6

International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...

Article type

Original Article


Article page

92-95


Authors Details

Vinod Babu S*, Jothimalar R , Krithika B , Santhi Silambanan


Article Metrics


View Article As

 


Downlaod Files

   






Article statistics

Viewed: 451

PDF Downloaded: 334


Assessment of iron status and its correlation with hepcidin in obese adults – A prospective case-control study


Original Article

Author Details : Vinod Babu S*, Jothimalar R , Krithika B , Santhi Silambanan

Volume : 8, Issue : 2, Year : 2021

Article Page : 92-95

https://doi.org/10.18231/j.ijcbr.2021.020



Suggest article by email

Get Permission

Abstract

Background: Obesity, broadly refers to increased body fat, which has become an important public health problem. Its prevalence continues to increase worldwide. In the World Health Survey, the prevalence of physical inactivity in India was 9.3% in men and 15.2% in women. Adipose tissue being an endocrine organ secretes several cytokines such as Interleukin-6, TNF-? and adipokines such as adiponectin, hepcidin, resistin. This study is to compare ferritin to iron and hepcidin with normal and obese men.
Methods: This case-control study was conducted at a multispecialty centre in Chennai, Tamil Nadu between 2013 and 2015, including 80 subjects of South Indian population. The biochemical parameters which were measured included the levels of hepcidin, ferritin, iron, Total Iron Binding Capacity and Hemoglobin.
Results: The results were statistically analyzed. Mann whitney U test performed to check for the statistical significance for differences in mean between the groups. The mean hepcidin values for the control group was 800.55 ± 503.50 and the study group was 1106.68 ± 826.25 and was found to be statistically significant with a p-value of 0.03. There was positive correlation of hepcidin with ferritin and Transferrin Saturation.
Conclusion: Hepcidin is recognized as the key regulator of systemic iron homeostasis. The measurement of hepcidin in biological fluids is therefore a promising tool in the diagnosis and management of medical conditions in which iron metabolism is affected.


Keywords: Ferroportin, Ferritin, Obesity, Hepcidin, Iron.


How to cite : Vinod Babu S, Jothimalar R, Krithika B, Silambanan S, Assessment of iron status and its correlation with hepcidin in obese adults – A prospective case-control study. Int J Clin Biochem Res 2021;8(2):92-95

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.