International Journal of Clinical Biochemistry and Research
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2394-6369
Online ISSN: 2394-6377
CODEN : IJCBK6
International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...Null
Author Details :
Volume : 1, Issue : 1, Year : 2014
Article Page : 46-53
Abstract
Background: Microalbuminuria (MAU) has been considered the first indication of renal injury in patients with diabetes and associated with a higher cardiovascular risk. It is evident from epidemiological studies that urine albumin concentration (UAC) or albumin: creatinine ratio (ACR) in spot urine sample gives similar result like 24-hour urinary albumin excretion (UAE).
Objectives: The study was aimed to find out whether UAC and/or ACR calculated in 24-hour urine sample correlate or not with same 24-hour UAE and what is diagnostic outcome by various measures of albumin excretion calculated in 24-hour urine samples in type 2 diabetic patients?
Methodology: We collected 24-hour urine sample from 125 type 2 diabetic patients and urinary albumin and creatinine were measured. We calculated different parameter of albumin excretion in 24-hour urine sample and interpretation of each parameter was derived. Data was expressed as median and range. Results: The median ACR was 187.30 (mg/g), UAC was 135.5 (mg/L) and UAE was 270.92(mg/24 hours) in 24-hours urine sample. Clinical outcome of nephropathy by different calculated measures of albumin excretion in 24-hour sample was different. 72 patients had similar interpretation while 53 patients showed different diagnostic interpretation by different measures of albumin excretion in the same 24-hour urine sample.
Conclusion: Various measures of urine albumin excretion like UAC, ACR calculated in 24-hour urine sample in type 2 diabetic patients showed different diagnostic interpretation. We recommend when the urinary albumin concentration exceeds 10 mg/L in spot or random urine sample, another 24-hour sample should be collected for confirmed diagnosis of the stage of the albuminuria / nephropathy. We conclude that 24-hour urine sample is gold standard for diagnosis of nephropathy in diabetic patients. Further prospective studies are needed to confirm our findings.
Key Words: Microalbuminuria, Type 2 diabetes mellitus, Urine albumin concentration, albumin: creatinine ratio, Urinary albumin excretion, 24-hour urine, Diabetic nephropathy, Measures of albuminuria.
How to cite : Chavan D V U, Durgawale D P P, Sontakke D A V, Lad D H D, STUDY OF VARIOUS MEASURES OF URINE ALBUMIN EXCRETION IN 24-HOURS URINE AND THEIR CLINICAL OUTCOME IN TYPE 2 DIABETIC PATIENTS.. Int J Clin Biochem Res 2014;1(1):46-53
This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
