International Journal of Clinical Biochemistry and Research
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2394-6369
Online ISSN: 2394-6377
CODEN : IJCBK6
International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...Null
Author Details :
Volume : 1, Issue : 1, Year : 2014
Article Page : 59-66
Abstract
Glioblastoma multiforme (GBM) is the most common primary tumor of a central nervous system, with the IV grade of histological malignancy. Despite the advancement of GBM treatment strategies the overall survival in GBM patients is still less than one year and it is probably due to location of the tumor and its high proliferative as well as metastasis activity. Thus, there is an urgent need to intensify basic as well as clinical research on GBM for understanding the molecular biology of the diseases and for the treatment of brain tumor. Most of therapeutic and molecular studies are performed with using of commercially available GBM cell lines. Use of the right cell line, which is based on the precise knowledge of its characteristics, may not only facilitate to design the experiments but it also provides more authentic information from the study. Thus, the aim of this study is to present the characteristics of the U-87glioblastoma cell line, which is the most frequently used in brain tumor research. In the presented article there are the information indicating the similarities in U-87 cells and spontaneous GBM biology, description of current studies with using this cell line, as well as benefits of choosing U-87 cell line in researches.
Keywords: U-87glioblastoma cell line; Brain tumor; Glioblastoma multiforme; Malignancy.
How to cite : Urbańska K, Mandal C C, ADVANCED VIEWS OF GLIOBLASTOMA MULTIFORME U-87 CELLS FOR THERAPY OF BRAIN TUMOR. Int J Clin Biochem Res 2014;1(1):59-66
This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
