International Journal of Clinical Biochemistry and Research
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2394-6369
Online ISSN: 2394-6377
CODEN : IJCBK6
International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...Null
Author Details :
Volume : 1, Issue : 1, Year : 2014
Article Page : 67-70
Abstract
Malaria has long been considered as disease associated with innate and adaptive immune response. The innate immune response, in particular, has widely been studied and implicated to the lethality in malaria. A sequence of immune events contributes to the cerebral manifestation commonly known as cerebral malaria (CM). CM is morbid and mostly irreversible condition which is accompanied by a haywire immune response that destroys the cerebro-protective mechanism of the host. Variety of immune components such as lymphocytes, mono/mac cells, cytokines, chemokines and their receptors have been attributed to this phenomenon. In this review we have attempted to highlight the role of chemokines and their receptors. Using evidences from ECM, we advocate that chemokine receptor such as CCR1, CCR2, CCR5 and CXCR3 contribute towards the pathogenesis. Also the set of chemokines binding to these receptors were over-expressed in CM. Overexpression results in the T Cell and monocyte activation and consequently migration across the blood brain barrier to cause the damage.
Keywords: Cerebral Malaria, Chemokines, Chemokine Receptors, CXCR3, CXCL4
How to cite : Srivastava K, Srivastava K, The Involvement of Chemokines and Receptors in Progression of Cerebral Malaria: The Story So Far (Chemokine and Their Receptors' Role in Experimental Cerebral Malaria). Int J Clin Biochem Res 2014;1(1):67-70
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