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The role of exosomal survivin in the diagnosis of breast cancer

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Original Article

Author Details : Mustafa Yıldırım, Hülya Çiçek, Gülper Nacarkahya, Özlem Nuray Sever, Necla Benlier, S Ravichandran*, Zeliha Yıldırım, R M Madhumitha Sri

Volume : 9, Issue : 3, Year : 2022

Article Page : 254-259

https://doi.org/10.18231/j.ijcbr.2022.049

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Abstract

Breast cancer is the leading cause of death in women across the globe. The aim of this study is to compare exosomal survivin levels in breast cancer patients and healthy population. It is also to investigate the relationship between clinicopathological parameters of breast cancer and exosomal survivin levels. Patients who were diagnosed with histopathologically confirmed breast cancer and healthy volunteers were included in the study. Serum samples from patients and healthy volunteers were stored at -80?. Exosomes were isolated from these serum samples. The integrity of the exosomes was disrupted. Survivin levels were measured by Enzyme Linked Immuno Sorbent Assay. Data on clinicopathological parameters were obtained from patient files and compared statistically.
 

Keywords: Breast cancer, Exosome, Survivin.

How to cite : Yıldırım M, Çiçek H, Nacarkahya G, Sever à N, Benlier N, Ravichandran S, Yıldırım Z, Sri R M M, The role of exosomal survivin in the diagnosis of breast cancer. Int J Clin Biochem Res 2022;9(3):254-259

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