International Journal of Clinical Biochemistry and Research
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2394-6369
Online ISSN: 2394-6377
CODEN : IJCBK6
International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...Original Article
Author Details :
Volume : 3, Issue : 1, Year : 2016
Article Page : 11-15
Abstract
Background and Objectives: Preeclampsia (PE), a hypertensive disorder unique to pregnancy and contributes to majority of maternal and perinatal morbidity and mortality. The triggering event in preeclampsia is postulated to be placental ischemia and endothelial dysfunction. In this context the present study was undertaken to investigate serum levels of nitric oxide, thiobarbituiric acid reacting substances (TBARS) and Vitamin E (Vit E) and their correlation with blood pressure in preeclamptic pregnant women.
Methods: Fifty clinically diagnosed preeclampsia patient and fifty age and trimester matched normotensive pregnant women were included in the study. Fasting venous sample were collected and nitric oxide, TBARS and vitamin E levels were measured.
Results and Interpretation: The mean values of serum nitric oxide, TBARS were significantly higher (< 0.001) in women with preeclampsia when compared to normotensive group whereas vitamin E levels were significantly lower among cases than the control group. Also observed that nitric oxide levels and TBARS positively correlated and vitamin E negatively correlated with the blood pressure and correlations were statistically significant.
Conclusions: The findings of present study points increased oxidative stress and decreased antioxidant levels may result in endothelial cell dysfunction. The levels of nitric oxide, TBARS and vitamin E could be used to assess the severity of preeclampsia in addition to other clinical and laboratory parameters.
Key words: Preeclampsia, oxidative stress, nitric oxide, vitamin E, blood pressure
How to cite : Rani N A, Naidu J N, Appraisal of Oxidative Stress Markers, Vitamin E and their Correlation with Blood Pressure in Preeclampsia: A Case Control Study. Int J Clin Biochem Res 2016;3(1):11-15
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