---

Relevance of allergen specific immunoglobulin e testing in Indian population: A retrospective study

---

Review Article

Author Details : Flavia J Almeida*, Jasmin Surana, Alap Christy, Raj Jatale, Shibani Ramchandani

Volume : 10, Issue : 1, Year : 2023

Article Page : 2-13

https://doi.org/10.18231/j.ijcbr.2023.002

Suggest article by email

Get Permission

---

Abstract

Prevalence of allergies has increased dramatically in recent decade and is now considered major chronic disease at the global level. Measurement of total and allergen specific IgE (Immunoglobulin E) is often requested to assess possible allergy. The main objective of our study was to understand the relevance of allergen specific IgE testing in Indian population. This retrospective study was conducted at a Global Reference Laboratory in Mumbai from May 2020 to May 2022. Total available data of 65431 patients was included in the study. The data was sub grouped as per age group, gender, and positivity for specific allergens. Of the total 65431 patients, 34601 (52.88%) were Females and 30830 (47.12%) were Males. Among those tested for specific IgE allergen, positivity was found to be 30%. The dust allergy was the most prevalent (62.18%) followed by Insect allergy (52.69%) and food allergy (51.78%). Out of the 18377 patients tested for Specific allergens, 7340 (39.94%) had at least one allergen positive. The availability of multiple and allergen specific panels has proved to be a major tool for the detection and diagnosis of multiple allergies. Detection of allergy is necessary to avoid wrong diagnosis and mismanagement of disease. Combination of total IgE with specific IgE can be used as evidence of allergy along with clinical findings. It is recommended to proceed with clinically appropriate allergen specific IgE tests, regardless of total IgE concentration in patients with a history of an acute allergic reaction.
 

Keywords: Allergy, Food allergy, ImmunoCAP, Specific IgE, Screening, Total IgE, Respiratory allergy.

How to cite : Almeida F J, Surana J, Christy A, Jatale R, Ramchandani S, Relevance of allergen specific immunoglobulin e testing in Indian population: A retrospective study. Int J Clin Biochem Res 2023;10(1):2-13

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.