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Assessment of alpha-fetoprotein clinical performances in the diagnosis of the hepatocellular carcinoma at Sominé DOLO Hospital of Mopti

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Original Article

Author Details : Modibo Coulibaly*, Adama Kondé, Djibril Traoré, Ousmane Bah, Valentin Sagara, Bakary Maiga

Volume : 10, Issue : 2, Year : 2023

Article Page : 163-170

https://doi.org/10.18231/j.ijcbr.2023.028

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Abstract

Background: Serum AFP has a poor clinical performance values especially when it comes to dealing with the early and AFP-negative diagnostic of HCC. This study aimed to assess the contribution of AFP in the diagnosis of HCC.

Materials and Methods: A total of 95 subjects were in a prospective observational study by consecutive and divided into two groups. The first group was made up with subjects in whom the diagnosis of HCC had been retained the second was the control group which was free of HCC. AFP levels were performed by on the e411®. Data were captured in Excel and analyzed by Ri386 version 4.1.2 binary for macOS 10.13.

Results: Log of AFP median of AFP in HCC subjects was significantly greater than in non HCC subjects 6.91 / versus 1.43 /, p-value < 0.001. At the cut-off of 200 /, the clinical performances showed an acceptable sensitivity 97.1% CI 95% [93.7 – 100] but a poor specificity 73,8% CI 95% [64.9 – 82.6] and out of the 34 cases of HCC, one case (2.9%) was AFP-negative HCC.

Conclusion: Our data show an acceptable sensitivity but a weak specificity of AFP as a for HCC at a cut-off 200 /. This suggests that AFP should be used with other , mainly for the early and AFP-negative HCC diagnosis.

Keywords: Alpha- fetoprotein, Diagnostic performance, Hepatocellular carcinoma.

How to cite : Coulibaly M, Kondé A, Traoré D, Bah O, Sagara V, Maiga B, Assessment of alpha-fetoprotein clinical performances in the diagnosis of the hepatocellular carcinoma at Sominé DOLO Hospital of Mopti. Int J Clin Biochem Res 2023;10(2):163-170

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