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Adverse pregnancy outcome in low PAPP-A levels: First trimester screening hospital based study

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Original Article

Author Details : Ankur Jindal*, Sunil Kumar Polipalli, Seema Kapoor, Ranjana Mishra

Volume : 10, Issue : 3, Year : 2023

Article Page : 200-203

https://doi.org/10.18231/j.ijcbr.2023.035

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Abstract

Objectives: To assess the adverse pregnancy outcome in Low Pregnancy Associated Plasma Protein -A (PAPP-A) levels in serum.
Materials and Methods: This is a prospective cohort study, which included 2150 pregnant women who attended the antenatal clinic of Obstetrics and Gynecology in the Lok Nayak Hospital, New Delhi, India. Blood samples were collected by the venipuncture method for First trimester screening to assess free β-hCG and PAPP-A concentrations were measured by Auto DELFIA (Perkin Elmer, Turku, Finland)
Results: In this study a total of 210 women who have the low PAPP-A value less than 0.4 MoM were under the closer surveillance for serious pregnancy outcome. 33(15.6%) women had pre-eclempsia, 27 (12.9%) cases showed intra-utrine growth retardation (IUGR), 6 (3.0%) cases have intra-utrine death. 48 (22.8%) women have pregnancy induced hypertension, and 96(45.6%) cases have other pregnancy related complication.
Conclusion: Low PAPP-A levels gives an indication of adverse pregnancy outcome in the early gestation age during the first trimester.
 

Keywords: First trimester screening, Low PAPP­A, Adverse pregnancy outcome.

How to cite : Jindal A, Polipalli S K, Kapoor S, Mishra R, Adverse pregnancy outcome in low PAPP-A levels: First trimester screening hospital based study. Int J Clin Biochem Res 2023;10(3):200-203

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