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Comparison of two parathyroid hormone (pth) assay methods in the monitoring of black african hemodialysis patients in the ivory coast (Maglumi® vs Vidas Biomerieux® Kits)

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Original Article

Author Details : Yao Epse Yapo Carine Mireille*, Yayo Sagou Eric, Kouacou Kadio Morel, Konan Konan Jean-Louis, Kone Dakouri Benedicte

Volume : 10, Issue : 4, Year : 2023

Article Page : 284-288

https://doi.org/10.18231/j.ijcbr.2023.052

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Abstract

Background: Parathyroid hormone (PTH) testing is recommended once or twice a year to prevent bone complications resulting from chronic kidney disease. However, its interpretation is subject to many factors, including the generation of the PTH test used. For this reason, it is recommended that each laboratory establish its own PTH Upper Limit of Normality (ULN). In order to guarantee optimal management of hemodialysis patients in the public sector in Côte d'Ivoire (West Africa), it proved important to compare the diagnosis of hyperparathyroidism made using two platforms used in the laboratory in charge of monitoring these patients: PTH VIDAS® (3rd Generation) and PTH MAGLUMI® (2nd Generation).
Materials and Methods: This was a cross-sectional study of 65 haemodialysis patients in Abidjan. PTH determinations were performed simultaneously on VIDAS® and MAGLUMI® platforms. The results obtained were interpreted on the basis of PTH threshold values pre-established in the laboratory.
Results: 86.15% of patients had concordant diagnoses on both platforms, compared with 13.85% with discordant diagnoses. Statistical analysis of these results showed a non-statistically significant difference.
Discussion: The limitation posed by differences in PTH concentration given by different platforms can be circumvented by using PTH ULN stablished for each platform for a given population. Conclusion: The diagnoses made by the two platforms are thus superimposable using their respective PTH ULN.
 

Keywords: PTH, Vidas® kit, Maglumi® kit, Comparison.

How to cite : Mireille Y E Y C, Eric Y S, Morel K K, Jean-louis K K, Benedicte K D, Comparison of two parathyroid hormone (pth) assay methods in the monitoring of black african hemodialysis patients in the ivory coast (Maglumi® vs Vidas Biomerieux® Kits). Int J Clin Biochem Res 2023;10(4):284-288

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