International Journal of Clinical Biochemistry and Research
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2394-6369
Online ISSN: 2394-6377
CODEN : IJCBK6
International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...Original Article
Author Details :
Volume : 11, Issue : 1, Year : 2024
Article Page : 39-45
https://doi.org/10.18231/j.ijcbr.2024.007
Abstract
Background: Sickle cell anaemia (SCA) is a public health problem. Zinc and Magnesium are essential metal antioxidants important in protection of erythrocytes membrane from oxidative stress; a trigger of vaso- occlusive crisis.
Aim: This study aims to evaluate the serum levels of zinc and magnesium in steady state sickle cell children with or without anaemia.
Settings and Design: Comparative cross-sectional study. Forty children aged 1-15 years with sickle cell disease (SCD) in steady state with or without aneamia and 40 age- and- sex matched HbAA counterparts (non-SCD) were consecutively recruited for the study.
Methods: Each forty SCD and non-SCD children were included in the study. Haemoglobin variants were analysed using haemoglobin electrophoresis. Packed cell volume was determined using haematocrit centrifuge and reader. Serum zinc and magnesium were assayed colorimetrically. Data were analysed using SPSS version 26. Student unpaired t- test was employed to assess the significance of the differences. p-value <0>
Results: Serum magnesium unlike zinc was significantly (p<0>0.05) effect of SCD and anaemia on serum zinc.
Conclusion: This study has shown that serum Mg was significantly lower in children with SCD compared to non-SCD counterpart.
Keywords: Anaemia, Children, Colorimetric, Haemoglobin, Magnesium, Nigeria, Sickle cell, Zinc
How to cite : Okoli C A, Dadang J, Deffi F, Ofakunrin A O, Serum zinc and magnesium levels in steady state sickle cell children with or without anaemia attending Jos University Teaching Hospital, North-Central Nigeria. Int J Clin Biochem Res 2024;11(1):39-45
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