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Hypovitaminosis D among type 2 diabetes patients and non-diabetics at Libreville

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Original Article

Author Details : Rosalie Nikiema-Ndong*, Aude Syntia Mbang Bengone, Elisabeth Lendoye, Marie Lauraine Eyeng Singui, Alvine Sibylle Batou, Felix Ovono Abessool

Volume : 11, Issue : 1, Year : 2024

Article Page : 46-51

https://doi.org/10.18231/j.ijcbr.2024.008

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Abstract

Background: Type 2 diabetes is resulting from insulin resistance and/or progressively reduced insulin secretion. Vitamin D nuclear receptor present on the β cells of the pancreas promotes the growth, synthesis and secretion of insulin. Furthermore, vitamin D deficiency has been associated with numerous disorders, such as type 2 diabetes, cardiovascular diseases, arterial hypertension, cancer, multiple sclerosis, depression, psychiatric diseases.
Aim: Determine the frequency of hypovitaminosis D among type 2 diabetes patients and those without diabetes in Libreville.
Materials and Methods: The study population was composed of 92 type 2 diabetes patients (cases) and 100 non-diabetics (controls). The vitamin D and glycated hemoglobin were performed using 25 OH Vitamin D total kit and FIA8000 kit respectively. The blood glucose, calcemia and phosphorus were performed using standard spectrophotometric assay.
Results: Insufficient vitamin D (<30ng xss=removed xss=removed> Conclusion: High hypovitaminosis D was found among cases and controls. Therefore and in regards of studies based on vitamin D supplementation, with an appropriate concentration of vitamin D or calcitriol, glucose homeostasis may be maintained. Moreover, implementation of preventive measures should be done to avoid disastrous consequences of vitamin D insufficiency.

Keywords: Hypovitaminosis D, Blood glucose, Calcitriol, Type 2 diabetes, Non­diabetics, Libreville

How to cite : Nikiema-ndong R, Bengone A S M, Lendoye E, Singui M L E, Batou A S, Abessool F O, Hypovitaminosis D among type 2 diabetes patients and non-diabetics at Libreville. Int J Clin Biochem Res 2024;11(1):46-51

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