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Comparison of degree of endothelial dysfunction in diabetic patients with and without dyslipidemia

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Original Article

Author Details : Sandeesha Veeranki*, Ravi Kiran, Usha Kiran

Volume : 11, Issue : 2, Year : 2024

Article Page : 93-99

https://doi.org/10.18231/j.ijcbr.2024.016

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Abstract

Background: Atherosclerosis in patients with type 2 diabetes is multifactorial. Among other factors, dyslipidemia and increased levels of oxidized LDL are important pathogenic mechanisms of endothelial dysfunction in patients with diabetes. Non-invasive method of assessment of endothelial function by brachial artery flow-mediated vasodilatation (FMD), provided an extremely useful tool for clinical application.
Materials and Methods: 90 patients attending the medicine and endocrinology departments were included in the study. Informed consent was obtained from all the study subjects. Clinical examination: Blood pressure (BP) and body-mass index (BMI); biochemical assessment, which included fasting blood sugar (FBS) and post-prandial blood sugar levels; and comprehensive lipid profile. The brachial artery diameter was measured on B-mode ultrasound images. FMD was calculated. Severe endothelial dysfunction was defined as FMD < 4> Results: The average FMD among controls was 14.76±2.17%, and among diabetics was 7.17±5.1%. Within the dyslipidemia subgroup, FMD was markedly reduced with an average dilatation of 5.74±5.02. Severe endothelial dysfunction was prevalent in 26% of the diabetics. Endothelial dysfunction could not be demonstrated in controls. Among patients with diabetic dyslipidemia, the prevalence of ED was 41%.
Conclusion: The present study findings may have implications about the origins of vascular disease in type 2 diabetes as well as patients with dyslipidemia. The ultrasound assessment of arterial FMD responses might provide a valuable tool for risk stratification of patients with type 2 diabetes, especially for those with dyslipidemia.

Keywords: Endothelial dysfunction, Dyslipidemia, Diabetes, Arterial flow-mediated dilatation

How to cite : Veeranki S, Kiran R, Kiran U, Comparison of degree of endothelial dysfunction in diabetic patients with and without dyslipidemia. Int J Clin Biochem Res 2024;11(2):93-99

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