International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377

CODEN : IJCBK6

International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...

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Original Article


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171-177


Authors Details

Mandeep Kaur*, Sahiba Kukreja, Siddhant Arora, Sukhjeet Kaur, Manmeet Kaur Gill


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sFlt-1/PLGF ratio: A promising marker for early detection of preeclampsia in the second and third trimester


Original Article

Author Details : Mandeep Kaur*, Sahiba Kukreja, Siddhant Arora, Sukhjeet Kaur, Manmeet Kaur Gill

Volume : 11, Issue : 3, Year : 2024

Article Page : 171-177

https://doi.org/10.18231/j.ijcbr.2024.026



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Abstract

Introduction: Preeclampsia (PE), characterized by endothelial dysfunction, remains a significant concern in obstetrics due to its association with maternal and fetal morbidity and mortality. One significant contributor to the clinical manifestations of PE is the imbalance in the placental release of various angiogenesis regulatory factors into the maternal circulation. Low levels of the pro-angiogenic biomarker Placental Growth Factor (PLGF) and high levels of antiangiogenic biomarker sFlt-1 (soluble Fms like tyrosine kinase -1) levels are detectable several weeks before the clinical presentation of PE, making them a promising marker for early diagnosis.
Aim: This study investigates the utility of the sFlt-1/PLGF ratio in predicting and diagnosing preeclampsia during the second and third trimesters of pregnancy.
Materials and Methods: A prospective cohort study was conducted with 150 study participants comprising normotensive controls and preeclamptic cases, diagnosed based on blood pressure and proteinuria criteria. Serum samples collected in the second trimester (24-28 weeks) and third trimester (>28 weeks) were analyzed for PLGF and sFlt-1 levels using ELISA kit method. The sFlt-1/PLGF ratio was calculated and evaluated for its diagnostic accuracy through ROC curve analysis.
Results: Significantly lower PLGF levels and higher sFlt-1 levels in preeclamptic pregnancies compared to normotensive pregnancies were seen in both trimesters (p < 0>


Keywords: Diagnostic marker, sFlt-1/PLGF ratio, Endothelial dysfunction, Angiogenic imbalance pregnancy complications


How to cite : Kaur M, Kukreja S, Arora S, Kaur S, Gill M K, sFlt-1/PLGF ratio: A promising marker for early detection of preeclampsia in the second and third trimester. Int J Clin Biochem Res 2024;11(3):171-177

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