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Diagnostic potential of elevated leptin in metabolic syndrome: A comprehensive review and meta-analysis

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Review Article

Author Details : Neha Dharmesh Sheth*, Ivvala Anand Shaker, Santosh Bidwe

Volume : 11, Issue : 4, Year : 2024

Article Page : 214-222

https://doi.org/10.18231/j.ijcbr.2024.032

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Abstract

Metabolic syndrome (MetS) poses a substantial global health concern linked to rising rates of obesity and sedentary behaviors. Insulin resistance and dysregulated adipokines are central to its development, including elevated leptin levels. Produced mainly by adipocytes, leptin plays a pivotal role in regulating appetite, energy expenditure, and insulin sensitivity, thereby influencing the pathophysiology of MetS. However, earlier investigations have reported conflicting findings between circulating leptin levels concerning MetS. A systematic search of major research databases identified 14 eligible studies published before June 2023. Employing a random-effects model, the meta-analysis examined leptin concentrations in 1,106 patients with MetS and 1,171 control subjects. The analysis revealed significantly higher circulating leptin levels in MetS individuals with the condition compared to healthy controls with SMD: 0.84, 95% CI: 0.74 to 0.96, Z = 3.10, p < 0>  

Keywords: Circulating leptin, Leptin, Metabolic Syndrome, Meta­analysis

How to cite : Sheth N D, Shaker I A, Bidwe S, Diagnostic potential of elevated leptin in metabolic syndrome: A comprehensive review and meta-analysis. Int J Clin Biochem Res 2024;11(4):214-222

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