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Biochemical markers of renal functions in hypothyroidism – A study in Indian population

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Original Article

Author Details : Vishnu Kumar*, Payal Gamit, H.B Sirajwala

Volume : 11, Issue : 4, Year : 2024

Article Page : 241-247

https://doi.org/10.18231/j.ijcbr.2024.036

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Abstract

Introduction: The global burden of hypothyroidism is significant among the disorders of thyroid gland. In the developed world, hypothyroidism prevalence is approximately 4-5% and that of subclinical hypothyroidism is approximately 4-15%.The present study was done to evaluate the association between thyroid function and renal parameters among euthyroid, subclinical and overt hypothyroid individuals.
Aim: To evaluate the renal functions in hypothyroid patients.
Objectives: To estimate & compare, freeT3, freeT4, TSH, serum creatinine, urea and uric acid, eGFR, urinary microalbumin, urinary creatinine levels in euthyroid (control group) & hypothyroid patients (study group).To calculate & compare urinary albumin to creatinine ratio (UACR) in both groups (control group and study group).
Materials and Methods: This is a Cross sectional analytical study carried out at Clinical Chemistry Laboratory, at Sir Sayajirao General Hospital (S.S.G.H) and Medical College Baroda, Vadodara. Study subjects were divided into three groups depending upon the levels of the TSH and free T4.
Materials and Methods: The Chemiluminescent Immunoassay (CLIA) was used to measure: S.TSH, fT4 and fT3 levels by micro particle enzyme immunoassays.
The Fully automatic Erba XL 640 was used to measure-
Serum Creatinine, Serum Urea, Serum Uric acid were measured on Erba XL 640.
The semiautomatic Microlab RX-50V was used to measure-Urinary Microalbumin.
All statistical analysis was done by using MedCalc statistical software.
ANOVA comparison analysis, we found significant differences in mean results of several parameters in three thyroid groups. In overt hypothyroid subjects, free T4 levels showed significantly moderate strong negative correlations (p=0.002, r= -0.412 & p<0 p=0.04, r=0.28) xss=removed r=0.57 xss=removed r=0.72). p=0.01, xss=removed p=0.00, xss=removed xss=removed> Conclusion: Present study were found increased levels of serum creatinine, uric acid, urine albumin creatinine ratio, urinary microalbumin and decreased eGFR levels in hypothyroid group as compared to euthyroid group. The prevalence of microalbuminuria and urine albumin creatinine ratio is high in overt hypothyroidism.
 
Keywords: Hypothyroid, Thyroid function, Serum creatinine, Urinary microalbumin, UACR

How to cite : Kumar V, Gamit P, Sirajwala H, Biochemical markers of renal functions in hypothyroidism – A study in Indian population. Int J Clin Biochem Res 2024;11(4):241-247

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