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To study an alteration in biochemical parameters in acute and chronic phase of respiratory acidosis and alkalosis

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Original Article

Author Details : Anita M Raut, D.V. Andure, Dilip Mhaisekar, Smita Mhaisekar, R.K. Padalkar

Volume : 3, Issue : 3, Year : 2016

Article Page : 280-284

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Abstract

Introduction: The primary abnormality in respiratory acidosis is retention of CO₂ (increased H₂CO₃) due to impaired alveolar ventilation resulting in a rise in pCO₂ causing acidemia. However, respiratory alkalosis occurs when there is decrease in H₂CO₃ concentration. A fall in pCO₂, reduces the ratio of carbonic acid to bicarbonate resulting in alkalemia.
Aim: To study variations in biochemical parameters in respect to respiratory acidosis and alkalosis.
Material and Methods: The biochemical parameters of respiratory acidosis and alkalosis like blood pH, concentration of CO₂, pO₂, pCO₂, level of HCO₃^-.
Results: The studied components of respiratory acidosis and alkalosis were found to be highly significant in chronic conditions of respiratory acidosis and alkalosis (p<0.01) than acute condition of respiratory failure when compared with the healthy controls.
Conclusion: In this study, we observed that there is marked increase in product of metabolism in acute and chronic phase of respiratory syndrome when compared with the healthy controls.

Keywords: Respiratory acidosis, respiratory alkalosis, blood pH, pO₂, pCO₂, HCO₃^-

How to cite : Raut A M, Andure D, Mhaisekar D, Mhaisekar S, Padalkar R, To study an alteration in biochemical parameters in acute and chronic phase of respiratory acidosis and alkalosis. Int J Clin Biochem Res 2016;3(3):280-284

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