International Journal of Clinical Biochemistry and Research
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2394-6369
Online ISSN: 2394-6377
CODEN : IJCBK6
International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...Original Article
Author Details :
Volume : 3, Issue : 3, Year : 2016
Article Page : 299-303
Abstract
Background: Serum gamma glutamyl transferase (GGT) which is a simple and reliable marker of liver fat deposition leads to hepatic insulin resistance and long term hepatic insulin resistance may lead to type 2diabetes mellitus (DM). In this context, the present study was under taken to study the serum GGT levels and its possible associations with serum triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C) and high density lipoprotein cholesterol (HDL-D) in type 2 DM.
Material and methods: The study was conducted at HSK hospital, Bagalkot from Jan 2016 to Jun 2016. The diagnosis of DM was based on WHO criteria. Sixty subjects participated in each group (DM and Controls). Fasting sample was collected and fasting blood sugar (FBS), HbA1c, urea, creatinine, GGT, and lipid parameters were estimated. Data was analysed using SPSS software. Student’s t test and Pearson correlation was applied for quantitative data.
Results: The serum levels of FBS, PPBS, HbA1c, creatinine, urea, TG and VLDL were raised significantly in cases compared to controls, whereas serum HDL was significantly decreased in cases compared to controls (p=0.000). There was statistically significant (p=0.001) positive correlation between the TGL and GGT. HDL-C was significantly, negatively correlated with GGT.
Conclusion: There was positive correlation between GGT and TG, TC, LDL-C and VLDL-C, only TGL was significant, and there was significant negative correlation between HDL and GGT. Hence serum GGT can be used as marker of cardiovascular diseases in type 2 DM patients.
Key words: Diabetes mellitus, Gamma Glutamyl transferase, Lipid profile
How to cite : Kashinakunti S V, Kollur P B, Rangappa M, Kal G S, Correlation between Lipid parameters and gamma glutamyl transferase in type 2 diabetes mellitus. Int J Clin Biochem Res 2016;3(3):299-303
This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
