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Study of serum lactate dehydrogenase and lipid profile in patients with chronic cough

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Original Article

Author Details : Mahesh Basavaraj Madole, Dilip Bhave, Mamatha MT, Ankur Patel

Volume : 3, Issue : 4, Year : 2016

Article Page : 409-412

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Abstract

Background: Lactate dehydrogenase (LDH) enzyme is found in almost every tissues of the body and its level is increased in serum in many tissue damaging pathological disorders. Patients with chronic cough mostly have history of cigarette smoking and prone to airway inflammation. Documentary studies shows cigarette smoking is associated with altered lipid profile.
The aim of the present study is to assess whether there is alteration in the concentration of serum lactate dehydrogenase and lipid profile in patients with chronic cough by estimation of lactate dehydrogenase level and lipid profile in serum.
Material and Methods: It is a case control study consisting of 50 cases with chronic cough compared with 50 healthy controls. Serum level of lactate dehydrogenase, total cholesterol, and triglyceride, LDL, VLDL and HDL were estimated in both the study groups. Statistical analysis was done by using unpaired t test. Values were expressed as means and standard deviation (SD).
Results: Statistically significant increase in the levels of LDH was found in patients with chronic cough as compared to controls. Serum levels of LDL were increased significantly in cases as compared to controls. Serum levels of cholesterol, triglyceride VLDL and HDL were not altered in cases as compared to control.
Conclusion: Serum LDH level was increased in patients with chronic cough which may be due to respiratory tract inflammation commonly caused by smoking. Increased level of LDL in patients with chronic cough is significantly correlated with smoking.

Keywords: Chronic cough, Lactate dehydrogenase, Lipid profile, Smoking

How to cite : Madole M B, Bhave D, Mamatha Mt, Patel A, Study of serum lactate dehydrogenase and lipid profile in patients with chronic cough. Int J Clin Biochem Res 2016;3(4):409-412

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