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Reduced urinary calcium creatinine ratio - can it be used as an early predictor of hypertensive pregnancies?

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Original Article

Author Details : Nagalakshmi CS, Santhosh NU, Krishnamurthy N

Volume : 3, Issue : 4, Year : 2016

Article Page : 413-416

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Abstract

Introduction: Pregnancy induced hypertension (PIH) is a multifaceted syndrome with involvement of several important organs and it is associated with endothelial dysfunction. The results from many clinical studies show the relationship between the aggravation of the hypertensive complication and the change in concentrations of various chemicals in mother. Lowering of serum calcium and increase of intracellular calcium can cause an elevation of blood pressure in pre-eclamptic mothers. Hence in this study we propose to estimate urinary calcium-creatinine ratio, for early diagnosis of pre-eclampsia, with an intention to bring down maternal and fetal morbidity and mortality.
Methods: 50 hypertensive pregnant women and 50 age matched normotensive pregnant women were checked for their blood pressures, BMI and proteinuria by dipstick method. Sterile random mid-stream urine sample was used to estimate urinary calcium (OCPC method), urinary creatinine (Jaffe’s method) and its ratio CCR. Cut off value for CCR was taken as ? 0.04.
Results: Amongst the cases, 84% of the patients had CCR ? 0.04, in contrast to 6% of controls with CCR ? 0.04. Chi square (?²) value was 58.34 showing that ratio is highly significant (p<0.0001).
Conclusions: A single random urinary CCR may be used as an effective tool for the early diagnosis of hypertensive pregnancy and may identify population at greater risk to be included in primary prevention programmes. In addition, early supplementation of hypertensive pregnant women with calcium may significantly reduce the morbidity and mortality.

Keywords: Urine, Calcium creatinine ratio, Hypertensive pregnancy, Pre-eclampsia, Early predictor

How to cite : Nagalakshmi Cs, Santhosh Nu, Krishnamurthy N, Reduced urinary calcium creatinine ratio - can it be used as an early predictor of hypertensive pregnancies?. Int J Clin Biochem Res 2016;3(4):413-416

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