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Comparison of lipid profile and de-ritis ratio in ultrasound diagnosed non-alcoholic and alcoholic fatty liver disease

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Original Article

Author Details : Ramesh, Krishnaswamy D, Indumati V, Vijay V, Rajeshwari

Volume : 3, Issue : 4, Year : 2016

Article Page : 438-441

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Abstract

Introduction: Non-alcoholic fatty liver disease (NAFLD), is a major cause of chronic liver disease. NAFLD can progress to fibrosis, cirrhosis, liver failure and hepatocellular carcinoma, like alcoholic fatty liver disease (AFLD). However there are only few studies regarding lipid profile in NAFLD and AFLD that have been undertaken. Recently AST/ALT Ratio (also known as De-ritis Ratio), has been used as a marker of alcoholic liver disease. Hence this study was conducted to study the biochemical markers in NAFLD and AFLD.
Objectives: 1. To compare lipid profile and De-ritis ratio in ultrasound diagnosed NAFLD and AFLD 2. To assess the usefulness of these parameters to differentiate NAFLD from AFLD and also to monitor their prognosis.
Materials and Methods: 30 cases of USG diagnosed NAFLD and 30 cases of USG diagnosed alcoholic liver disease aged between 25 to 60 years, from MCH, VIMS, Ballari were studied and compared with 30 healthy age and sex matched healthy controls. After obtaining informed consent from all the patients, 5ml of fasting blood was collected and lipid profile, AST, ALT levels were estimated and De-ritis ratio was calculated.
Results: There was significant increase in the total cholesterol, LDL and Triglycerides levels in NAFLD patients (p=0.0001) when compared to AFLD patients. De-ritis ratio was significantly increased in AFLD patients (p=0.0001).
Conclusion: Hence it was concluded from our study that, NAFLD patients showed atherogenic dyslipidemia when compared to AFLD. De-ritis ratio can be used as parameter to differentiate between NAFLD from AFLD.

Keywords: Non-alcohol fatty liver, Alcoholic fatty liver, De-ritis ratio, Lipid profile, Fatty liver

How to cite : Ramesh, Krishnaswamy D, Indumati V, Vijay V, Rajeshwari, Comparison of lipid profile and de-ritis ratio in ultrasound diagnosed non-alcoholic and alcoholic fatty liver disease. Int J Clin Biochem Res 2016;3(4):438-441

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