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Study of oxidative stress and endothelial dysfunction in paediatric obesity

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Original Article

Author Details : Sarala Devi Tenepalli, Karunasree Yerrajwala, Lalitha Devi Seerla

Volume : 3, Issue : 4, Year : 2016

Article Page : 446-448

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Abstract

Introduction: Obesity is associated with complications like Diabetes, Asthma, Hypertension and cardiovascular risks which are to be managed of health care worldwide. Increased BMI during childhood and adolescence may lead to premature death from disease and may increase the risk of CVD at adult age.
Methods: 30 obese children with an age group of 8-15 years attending paediatric department and 30 healthy age matched non obese children were taken in the study. BMI was calculated for all and biochemical markers like fasting blood glucose, Insulin resistance (HOMA-IR) were determined using commercial enzymatic kits. MDA, FRAP, and NO was determined by chemical methods.
Results: A significant increased levels of BMI, Insulin and insulin resistance (HOMA-IR), MDA and NO levels (P<0.05) was observed in obese children compared to non-obese but,  the levels of Fasting blood sugar levels and FRAP were not statistically significant in cases compared to controls.
Conclusions: As childhood obesity can influence many risk factors like diabetes, hypertension, asthma, endothelial dysfunction which may lead to CVD risk and atherosclerosis most of the studies reported that there are possible chances to minimize these risk factors by proper medication and most of the events are even reversible. Therefore the parent should be suggested to have a proper dietary management and medication in order to avoid the progression of these risk factors in adulthood.

Keywords: Paediatric obesity, Endothelial dysfunction, Adipocytokines, Leptin, Vascular smooth muscle cells

How to cite : Tenepalli S D, Yerrajwala K, Seerla L D, Study of oxidative stress and endothelial dysfunction in paediatric obesity. Int J Clin Biochem Res 2016;3(4):446-448

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