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Homocysteine, folate and vitamin b12 status in patients with coronary artery disease in young age

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Original Article

Author Details : Patel J. D., Chakrabarti C.

Volume : 4, Issue : 2, Year : 2017

Article Page : 129-135

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Abstract

Introduction: Rising incidence of coronary artery disease in India which is rather common causes of morbidity and mortality is not good news. Even by conservative estimate Indian spending an amount that’s nearly 40% entire central Government health budget for the treatment of CAD. Hyperhomocysteinemia is considered as an independent risk factor of premature Coronary Artery Disease (CAD), but the probable role of homocysteine along with biochemically related folate & vitamin B₁₂ with homocysteine in early onset of CAD is not well studied in this part of country. The aim of this study was to assess the role of hyperhomocysteinemia, folate and vitamin B₁₂ deficiency in the development of premature CAD.
Materials and Methods: We have performed observational case-control study in total 200 participants having age more than 20 years in both male and female sex, out of these 100 are patients suffering from CAD who were admitted for selective coronary angiography in academic tertiary care hospital in Ahmedabad and 100 healthy controls group participants attended the said institute. The homocysteine, folate and vitamin B₁₂ concentration were measured using standard reagent kit on Abbott AxSYM close system.
Result: Mean homocysteine in study group was significantly higher in study group compare to control group (33.02+/-17.41 ?mol/l; 13.88+/-3.86 ?mol/l). Mean homocysteine level in each age group of study group patient is significantly high than the control group participant (P < 0.001). Mean folate and vitamin B₁₂ level is lower in each age group of study group patients than control group participants. Mean serum folate (7.13+/-3.46 ng/ml versus 12.35+/-3.36 ng/ml) and vitamin B₁₂ (156.41+/-127.36 pg/ml versus 449.86+/-169.90 pg/ml) level are lower in study group than the control group participants respectively. Folate and vitamin B₁₂ shows negative correlation with homocysteine. There was a significant positive correlation between homocysteine and age is observed while folate and vitamin B₁₂ shows negative correlation with age.
Conclusion: We may conclude from our study that increase homocysteine level may be one of the risk factor of CAD in young age. Our study also shows that age is non-modifiable while folate and vitamin B₁₂ deficiency are modifiable risk factor of hyperhomocysteinemia.

Keywords: Coronary Artery Disease; Homocysteine; Folate and Vitamin B₁₂

How to cite : Patel J. D., Chakrabarti C., Homocysteine, folate and vitamin b12 status in patients with coronary artery disease in young age. Int J Clin Biochem Res 2017;4(2):129-135

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