International Journal of Clinical Biochemistry and Research
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2394-6369
Online ISSN: 2394-6377
CODEN : IJCBK6
International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...Original Article
Author Details :
Volume : 4, Issue : 2, Year : 2017
Article Page : 154-158
Abstract
Background and Objectives: Obesity and related ailments are a major hassle across the world for many decades now. As per the published data from various sources overweight population between 1976 to 2002, [body mass index (BMI) ? 25 kg/m] in the USA has seen a steady increase from 46 to 66% along with the increase in that of obesity (BMI ? 30 kg/m2) from 15 to 31%.(1) Vascular endothelial growth factor (VEGF) is known factor in regulation of angiogenesis and tissue remodeling. It has been evident through various publications, the potential role VEGF plays in the control of energy metabolism and adipose tissue.(2) The current study is planned to be carried out in order to investigate clinically the correlation between blood serum VEGF concentrations with BMI and waist circumference in obese and lean subjects. The study was carried out on 30 obese subjects (overweight BMI between 25-29 kg/m2 and obese BMI >30 kg/m2) and 30 matching age and gender lean subjects (BMI < 25 kg/m2). Sandwich ELISA method was used to measure Serum VEGF. The measured values depicted mean and standard deviation of serum VEGF levels as 99.6±5. 1ng/mL in obese and 51.9 ± 7.2ng/mL in lean subjects [p value <0.005]. It was observed that increased levels of vascular growth factors were present in obese subjects compared to lean subjects. This may help protect against obesity and insulin resistance. With this new scientific evidence, we understand the importance of VEGF on the design of new treatment for obesity, obesity-related disorders and insulin resistance.
Keywords: Adipose tissue; Body Mass Index; Waist circumference; Vascular Endothelial Growth Factor
How to cite : Shet S K, Vishwanath H, Serum vascular endothelial growth factor-New scientific role in obesity. Int J Clin Biochem Res 2017;4(2):154-158
This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
