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Relationship between higher Serum ferritin levels, Insulin resistance marker and components of metabolic syndrome in Men and Women in west part of India

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Original Article

Author Details : B. Sudhakar, R.M. Shah

Volume : 4, Issue : 2, Year : 2017

Article Page : 168-174

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Abstract

Background: There are no effective studies in west part of India on relationship between higher serum ferritin levels in impaired glucose individuals, type 2 diabetes mellitus patients are markers for insulin resistance and reinforce to metabolic syndrome. The association between serum ferritin levels, insulin resistance marker (HOMA IR), Glycosylated Hemoglobin A1C with individual components of metabolic syndrome in type 2 diabetes mellitus, impaired fasting glucose, obesity and healthy subjects are unclear.   
Objectives: This research was delineated to find out the interrelation between serum ferritin levels with fasting glucose levels, waist hip ratio, fasting insulin levels, insulin resistance marker (HOMA-IR) and components of metabolic syndrome in type 2 diabetes mellitus patients, newly identified type 2 diabetes mellitus patients, Impaired fasting glucose subjects and healthy participants. To investigate any menopause transition effects on serum ferritin levels and components of metabolic syndrome for identifying insulin resistance and early diagnosis of type 2 diabetes mellitus in men and women of age 30-65 years.
Subjects and Methods: The number of individuals included in this study 1058, out of them 365 patients with previously diagnosed type 2 diabetes mellitus with poor and good glycemic control patients, 144 patients with newly identified type 2 diabetes mellitus, 189 with participants with impaired fasting glucose levels and 360 healthy participants. Ferritin levels in serum, fasting glucose in plasma, fasting insulin levels in serum, Glycosyalted HbA1c in blood and serum lipid levels were analyzed. Waist Hip ratio is measured. Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) is calculated.  
Results: In our analysis, out of 1058 participants, 289 individuals (27.2%) with increased levels of ferritin levels in which 46.6% (newly identified type 2 diabetes mellitus patients), 31.95% previously diagnosed type 2 diabetes mellitus 20.4% impaired fasting glucose subjects and 10.55% healthy participants. The odd ratios for men in newly diagnosed diabetes mellitus were 4.94 and for women 3.61. Linear regression analysis between serum ferritin, blood insulin, and glucose and glycosylated hemoglobin showed significant correlation.
Conclusion: our research findings suggest increased ferritin in blood as marker for insulin resistance and early indicator for diagnosis of type 2 diabetes. High ferritin in metabolic syndrome identify early indicator for insulin resistance and pre diabetes mellitus.

Keywords: Mets; GHB; HOMA-IR

How to cite : Sudhakar B, Shah R, Relationship between higher Serum ferritin levels, Insulin resistance marker and components of metabolic syndrome in Men and Women in west part of India. Int J Clin Biochem Res 2017;4(2):168-174

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