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Study of levels of malondialdehyde, super oxide dismutase and hsCrp in serum of non-obese patients with polycystic ovarian syndrome

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Original Article

Author Details : Zahoorunnisa Deba, Triveni A. Jambale, P. M. Gangadhara Swamy, D. S. Jayaprakash Murthy

Volume : 4, Issue : 2, Year : 2017

Article Page : 191-194

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Abstract

Background: Polycystic ovarian syndrome (PCOS) is a heterogenous disorder with diverse clinical features. PCOS patients are known to develop long term complications like cardiovascular disease (CVD), type 2 diabetes mellitus, endometrial cancer, breast cancer but increasing evidence shows presence of CVD in many PCOS patients. The key role in the pathophysiology of this disease is the presence of oxidative stress which is an important component of the cardiometabolic risk and is seen in obese women with PCOS. Presence of inflammation is indicative of future development of CVD. PCOS is a condition of low grade inflammation. This study was taken up to study the oxidant status and hsCrp levels in non-obese PCOS women.
Aim: To measure the levels of MDA, SOD and hscrp in serum of non-obese PCOS patient’s ànd non obese women without PCOS.
Materials and Method: A cross sectional study was conducted from December 2011 to December 2012. 60 age and BMI matched subjects were included in the study between 25 -35 years of age group; 30 non obese pcos women as cases and 30 non obese normal women as controls. In all subjects the serum levels of MDA, SOD, hscrp was measured by Nadiger et al method, Marklund and Marklund method and immunoturbidometry method respectively.
Results: Decreased serum levels of SOD and increased serum levels of MDA and hscrp was seen in PCOS women compared to normal women.
Conclusion: Development of CVD in non-obese PCOS women is due to presence of oxidative stress and inflammation as risk factors.

Keywords: Cardiovascular Disease, HSCRP, MDA, Oxidative Stress, Polycystic Ovarian Syndrome, SOD

How to cite : Deba Z, Jambale T A, Swamy P M G, Murthy D S J, Study of levels of malondialdehyde, super oxide dismutase and hsCrp in serum of non-obese patients with polycystic ovarian syndrome. Int J Clin Biochem Res 2017;4(2):191-194

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