Print ISSN: 2394-6369
Online ISSN: 2394-6377
CODEN : IJCBK6
International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...Original Article
Author Details :
Volume : 4, Issue : 4, Year : 2017
Article Page : 357-362
Abstract
Introduction: Diabetic nephropathy is a progressive renal complication of type-2 diabetes. Inflammation is found as main cause of diabetic nephropathy pathogenesis. Cytokines influence inflammatory and immune responses by their effects on cells. Chronic low-grade inflammation together with innate immune system activation is closely associated in diabetes mellitus pathogenesis and its micro-vascular complications.
Aim: The aim of this study is to estimate the level of pro- inflammatory marker IL-6 and microalbuminuria in subjects diabetic nephropathy compared to non-diabetic healthy subjects.
Materials and Method: The study was conducted at Government Medical College, Banda as well as M.L.N. Medical College, Allahabad (UP).The study was made on a group of 150 selected subjects. From these, 50 were healthy subjects without Diabetes and100 were patients of diabetic nephropathy of type-2 DM. They were evaluated by measurement of various parameters such as BP, blood parameters as FBS, HbA1c, lipid profile level, serum urea, serum creatinine, Serum albumin, A:G ratio and inflammatory marker like IL-6.
Results: Elevated Blood Pressure and serum levels of FBS, HbA1c, serum urea, serum creatinine, TC, TG, LDL, VLDL, IL-6 level and reduction in HDL, Serum albumin, A/G ratio were observed in diabetic nephropathy subjects. These values of biochemical markers were found to be significant statically.
Conclusion: An increase in the levels of inflammatory marker like IL-6 in DN patients with contrast to normal levels of these parameters shows a significant role in development of DN.
Keywords: Diabetic nephropathy, Glycosylated hemoglobin, Interleukins-6
How to cite : Sharma D, Dwivedi S, Singh B, Verma K, Narendra N, Status of pro-inflammatory Marker IL-6 and Microalbuminuria in type- 2 Diabetic Nephropathy subjects. Int J Clin Biochem Res 2017;4(4):357-362
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