International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377

CODEN : IJCBK6

International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...

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Original Article


Article page

405-407


Authors Details

Jeyachandran G, Madhubala V, Anusha R


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Establishment of reference interval for cord blood TSH


Original Article

Author Details : Jeyachandran G, Madhubala V, Anusha R

Volume : 4, Issue : 4, Year : 2017

Article Page : 405-407


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Abstract

Introduction: TSH values in the cord blood is useful for neonatal screening of thyroid disorders. Screening is essential to rule out congenital hypothyroidism in neonates without any physical signs. In South Indian population, the reference interval for cord blood TSH has not been established.
Aim: To establish the reference interval of cord blood TSH in South Indian population.
Methods and Material: This study was conducted at Dr. SMCSI Medical College, Karakonam, Trivandrum. 200 neonates were selected as reference individuals for cord blood collection. The rejection criteria were complications in the delivery or hypothyroidism in the mother or the neonate. TSH was estimated in the cord blood by chemiluminescence method in VITROS ECi.
Statistical Analysis: The data obtained was analyzed using SPSS version 16. Paired T test was used for statistical analysis. The reference interval was determined by nonparametric method by taking middle 95 percentile. Correlation analysis was done using Pearson correlation coefficient.
Results: The reference interval for cord blood TSH is 2.2 to 18 mIU/L. The results showed that there is no significant difference between male and female neonates as well as the normal and the Caesarean section. Correlation study showed that cord blood TSH level was independent of the gestational age. Hence subgroup reference interval was not required.
Conclusions: The reference interval for cord blood TSH is from 2.2 to 18 mIU/L. Establishment of subgroup reference interval is not required since there is no significant variation between male and female neonates as well as between normal and caesarean section.

Keywords: Cord Blood, TSH, Reference Interval

 


How to cite : Jeyachandran G, Madhubala V, Anusha R, Establishment of reference interval for cord blood TSH. Int J Clin Biochem Res 2017;4(4):405-407

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