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ASSESSMENT OF THYROID PROFILE IN METABOLIC SYNDROME PATIENTS: AN OPD BASED OBSERVATIONAL CASE-CONTROL STUDY IN A TERTIARY HOSPITAL OF BHUBANESWAR, ODISHA

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Author Details : Saumyajit Maiti, Dr. Kamal Lochan Das

Volume : 2, Issue : 2, Year : 2015

Article Page : 110-119

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Abstract

Introduction: Metabolic syndrome constitutes a cluster of risk factors characterized by abdominal obesity, hypertension, hyperglycemia, atherogenic dyslipidemia, prothrombotic and proinflammatory conditions. The prevalence of cardiovascular disease is 2–3 times higher in individuals with metabolic syndrome. Though this syndrome is highly prevalent in the developed countries, now it has a great tendency to encroach in developing countries like India. On the other hand, sub-clinical hyperthyroidism and overt hyperthyroidism are responsible for weight loss, fatigue, hyperglycemia, polyuria, polydipsia, atrial fibrillation, tachycardia, delirium, tremor, pretibial myxedema, etc. Similarly sub-clinical hypothyroidism and overt hypothyroidism are recognized risk factors for atherosclerotic cardiovascular disease, hyperlipidemia, low grade inflammation and hypercoagulability. Although metabolic syndrome and thyroid dysfunctions are established independent risk factors for cardiovascular disease, it is not clearly known whether there is any link between both entities. This study is an effort to investigate the association between metabolic syndrome & thyroid dysfunction.

Aims and Objectives: To estimate the thyroid hormones among the patients attending hospital with Metabolic Syndrome and to find out any relation from the result when was compared with the status of thyroid hormones of age-sex matched control group.

Methodology: In this cross-sectional, observational study, thyroid profiles were estimated in 150 metabolic syndrome patients of 30-60 age group as well as 150 age-sex matched normal individuals of same age group in the OPD of the Department of Medicine, Hi-Tech Medical College and Hospital, an urban area of Bhubaneswar, Odisha over a period of one and half year (September 2012 to February 2014).

Result: Though serum T3 and T4 levels are within the normal range but serum TSH level is remarkably increased of metabolic syndrome patients in comparison with that of the control group. And it is also observed that in the younger age group of metabolic syndrome patients, serum TSH levels are drastically increased in contrast to that of the same age group of controls.

Conclusion: From this study, we can draw a conclusion that the patients of metabolic syndrome have a tendency to produce a picture of sub-clinical hypothyroidism.

Keywords: Metabolic syndrome, Thyroid Profile, Central Obesity, Diabetic Profile, Lipid Profile, Hypertension, Subclinical hypothyroidism. 

How to cite : Maiti S, Das D K L, ASSESSMENT OF THYROID PROFILE IN METABOLIC SYNDROME PATIENTS: AN OPD BASED OBSERVATIONAL CASE-CONTROL STUDY IN A TERTIARY HOSPITAL OF BHUBANESWAR, ODISHA. Int J Clin Biochem Res 2015;2(2):110-119

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