International Journal of Clinical Biochemistry and Research
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2394-6369
Online ISSN: 2394-6377
CODEN : IJCBK6
International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...Original Article
Author Details :
Volume : 5, Issue : 2, Year : 2018
Article Page : 254-256
https://doi.org/10.18231/2394-6377.2018.0052
Abstract
Leukemias are malignant neoplasms of hematopoietic stem cells characterized by diffuse infiltration of the blood and bone marrow by neoplastic cells. Leukemias are classified as acute and chronic according to clinical course and myeloid and lymphoid according to the cell predominantly involved in leukemic process. Free radicals are implicated in the pathogenesis of leukemia. Oxidative destruction of polyunsaturated fatty acid is called as lipid peroxidation. In this study, we determined serum malonyldialdehyde (MDA) level as a lipid peroxidation product in patients with leukemia. The mean serum MDA levels were significantly increased in leukemic patients (p<0>significant difference in serum MDA levels with respect to sex only in patients with chronic myeloid leukemia. Whereas in age groups, we found significant trend in serum MDA levels in patients with CML, AML and ALL patients. There was no significant difference in serum MDA level in patients with CLL with respect to age. Our finding of the high levels of serum malondialdehyde in leukemic patients as compared to healthy control may be due to increased oxidative stress in patients with leukemia.
Keywords: Malondialdehyde, Leukemia, Oxidative stress
How to cite : Pujari K N, Jadkar S P, Patil C G, Kulkarni A, Tuljapurkar V B, Variations in serum malondialdehyde levels in patients with leukemia. Int J Clin Biochem Res 2018;5(2):254-256
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