International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377

CODEN : IJCBK6

International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...

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Original Article


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541-546


Authors Details

Bijoya P. Chatterjee, Sandip Sendhav*, Amit Kakaiya, Prasanta Chatterjee Biswas


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A comparative analysis of direct LDL-C assay and Friedewald’s formula in subjects of ischemic heart disease & stroke in a tertiary care centre


Original Article

Author Details : Bijoya P. Chatterjee, Sandip Sendhav*, Amit Kakaiya, Prasanta Chatterjee Biswas

Volume : 5, Issue : 4, Year : 2018

Article Page : 541-546

https://doi.org/10.18231/2394-6377.2018.0115



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Abstract

Introduction: Among the various risk factors for the development of Ischemic heart diseases (IHD) as well as stroke is elevated low density lipoprotein cholesterol (LDL-C) levels. This makes accurate reporting of LDL-C crucial in the management of IHD. On one hand estimation of LDL-C by direct method is available, but it is expensive and on the other hand the Friedewald’s formula is most commonly employed but a method with limitations.
Aim: Therefore the aim of this study is to evaluate the correlation between calculated LDL-C with direct LDL-C method and analyse their appropriateness.
Materials and Methods: This study was a hospital based cross-sectional study. LDL-C was measured by both Friedewald’s formula (FF) and direct LDL method in 501 participants between the age group of 30–70 years. Paired t-test was used to test the difference in LDL concentration obtained by a direct method and Friedewald’s formula. The level of significance was taken as P < 0> Results: The mean and standard deviation (SD) of LDL-C estimated by both direct assay and FF showed a significant difference (p<0>0.05) at TG range >400 mg/dL. There was a discrepancy of 37 out of 501participants (7.38%) classified as cardiac risk groups by the two methods used. A significant correlation between LDL-C levels obtained by FF and direct methods, (p value <0 xss=removed xss=removed> Conclusion: The study concludes that both methods can be employed depending on TG levels. Direct LDL estimation appears to be unreliable at TG concentrations >400 mg/dL but useful when sample is collected from a non-fasting participants.

Keywords: Low density lipoprotein, Ischemic heart disease, Stroke.


How to cite : Chatterjee B P, Sendhav S, Kakaiya A, Biswas P C, A comparative analysis of direct LDL-C assay and Friedewald’s formula in subjects of ischemic heart disease & stroke in a tertiary care centre. Int J Clin Biochem Res 2018;5(4):541-546

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