International Journal of Clinical Biochemistry and Research
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2394-6369
Online ISSN: 2394-6377
CODEN : IJCBK6
International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...Null
Author Details :
Volume : 5, Issue : 4, Year : 2018
Article Page : 627-630
https://doi.org/10.18231/2394-6377.2018.0133
Abstract
Introduction: Chronic obstructive pulmonary disease (COPD) which includes chronic bronchitis and emphysema is considered as a progressive type of respiratory tract disease and is characterized by structural changes such as emphysema, airflow limitation, dynamic hyperinflation, air trapping, and peribronchial fibrotic remodeling of the lungs with significant systemic inflammatory components, induced by chronic exposures to smoking and/or occupational or environmental sources.
Materials and Methods: This case control study was conducted on 60 subjects in which 30 were healthy controls and 30 were cases of COPD. Patients with history of respiratory disease other than COPD, cardiac diseases and neuromuscular disease were excluded. 30 healthy age and gender matched non-smoker adults were selected as control group.
Results: Unpaired t test was performed and it was observed that Total Cholesterol, Triglyceride, Low Density Lipoprotein, Lactate dehydrogenase levels were significantly higher and serum concentrations of High Density Lipoprotein was decreased significantly in cases as compared to controls.
Conclusion: Serum LDH levels are altered in many respiratory diseases but it has not been studied in depth in COPD patients. In view of this we conducted the study and our results shows that patients with COPD have raised serum LDH levels.
Keywords: Smoking, COPD, Lactate dehydrogenase.
How to cite : Sharma S K, Singh N , Thimmaraju K V, Tilak M, To study biochemical markers in chronic obstructive pulmonary disease patients. Int J Clin Biochem Res 2018;5(4):627-630
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