International Journal of Clinical Biochemistry and Research
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2394-6369
Online ISSN: 2394-6377
CODEN : IJCBK6
International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...Null
Author Details :
Volume : 6, Issue : 1, Year : 2019
Article Page : 56-60
https://doi.org/10.18231/2394-6377.2019.0015
Abstract
Introduction and Objective: Chronic inflammation & lipid peroxidation plays a pivotal role in the etiopathogenesis of cardiovascular risks in many clinical conditions. Whereas, Lichen planus (LP), is a chronic skin inflammatory disorder which disturbs lipid metabolism& increases the lipid peroxides. However, there are limited data about the correlation between oxidative stress & hypertriglyceridemia in LP, hence the study was undertaken to 1) Estimate the levels of TG (triglycerides) & MDA (malondialdehyde) levels & 2) to correlate between the MDA & TG levels in LP patients.
Materials and Methods: A case control study was done at KIMS hospital, Hubli, which included 50 LP patients and 50 healthy individuals. Serum levels of TG (GPO-PAP method) and MDA (TBA method) was done.
Result: Patients with LP presented higher significant TG values (182.93 vs. 113 mg? dl), MDA values (4.81 vs. 3.99 nmol/ml) vs. controls.Also,our study showed positive correlation between TAG & MDA levels which is statistically significant (0.012).
Interpretation and Conclusion: Thus,the present study showed increased levels of TG & MDA, indicating that hypertriglyceridemia & lipid peroxidation may have domino effect with each other due to chronic inflammation & thereby may increase the cardiovascular complications in LP patients.
Keywords: Atherosclerosis, Cardiovascular risks, Dyslipidemias, Chronic inflammation, Lichen planus, Oxidative stress.
How to cite : D.r M, M.c C , A correlation between oxidative stress and hypertriglyceridemia in lichen planus - A case control study. Int J Clin Biochem Res 2019;6(1):56-60
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